(J. Klepper, Aschaffenburg; updated 01.2007)

Fasting as a treatment for epilepsy has been known since biblical times. In the 1920ties the principle of the ketogenic diet was established as a systematic approach to treat intractable childhood epilepsy. It was an established therapy until the discovery of anticonvulsants led to decreased use of the diet. Recent years have seen a resurgence of the interest in the ketogenic diet, in particular as novel indications such as GLUT1 deficiency syndrome emerged.